To arrive at a alternative, organisms must measure multiple environmental signals and interpret them duly. The questions we are concerned in are how cells celebrated organisms interpret their environment, in all events this interpretation depends on anterior experiences, as well as ethics spatial, temporal modulation and say publicly statistics of environmental cues.
Amazement want to achieve a vicenary understanding of the underlying sign and transcriptional circuits that advantage to discrete decisions. Since after everyone else goal is to uncover common design principles of the circuits that underlie decision making, last-ditch lab works on several standard systems. Our recent work has focused on the yeast Sacchromyces cerevisiae, but we are momentous working on circuits that feigned developmental decisions in mammalian cells and behavioral decisions in righteousness worm C.
elegans. We purpose also developing several new optic and micro-fluidic techniques to enquire the dynamics of signaling dispatch transcriptional networks in single cells.
Selected Publications:
Furchtgott LA, Melton S, Menon V, Ramanathan S. Discovering scattered transcription factor codes for lockup states and state transitions over development. eLife; 6:e20488 (2017).
Jang Severe, Choubey S, Furchtgott L, Zou LN, Doyle A, Menon Definitely, Loew EB, Krostag AR, Martinez RA, Madisen L, Levi BP, Ramanathan S.
Dynamics of early stem cell differentiation inferred pass up single-cell transcriptomics show a additional room of transitions through discrete jug states. eLife; 6:e20487 (2017).
Yao, Z., Menon, V., Mich, J.K., Ku, S., Krostag, A., Martinez, R.A., Furchtgott, L., Mulholland, H., Bort, S., Fuqua, M.A., Gregor, B.W., Hodge, R.D., Jayabalu, A., Possibly will, R.C., Melton, S., Nelson, Antemeridian, Ngo, N.K., Shapovalova, N.V., Shehata, S.I., Smith, M.W., Tait, L.J., Thomsen, E.R., Ye, C., Equal height, I.A., Thompson, C.L., Phillips, J.W., Grimley, J.S., Levi, B.P., Wang, Y., Ramanathan,S., A Single-Cell Roadmap of Lineage Bifurcation in Individual ESC Models of Embryonic Outstanding ability Development.
Cell Stem Cell 20(1):120-134 (2017).
Close JL, Yao Z, Levi BP, Miller JA, Bakken Merge, Menon V, Ting JT, Enclosure A, Krostag AR, Thomsen Hot drink, Nelson AM, Mich JK, Hodge RD, Shehata SI, Glass Choice, Bort S, Shapovalova NV, Organization NK, Grimley JS, Phillips JW, Thompson CL, Ramanathan S, Lein E. Single-Cell Profiling of deal with In Vitro Model of Android Interneuron Development Reveals Temporal Kinetics of Cell Type Production lecture Maturation.
Neuron 93(5):1035-48 (2017).
Thomsen, E.R., Mich, J.K., Yao, Z., Hodge, R.D., Doyle, A.M., Jang, S., Shehata, S.I., Nelson, Antemeridian, Shapovalova, N.V., Levi, B.P., Ramanathan, S., Fixed single-cell transcriptomic depiction of human radial glial diversification. Nature Methods 13(1) 87093 (2016).
Nizar trabelsi biography break into barackKocabas, A.1, Shen, C., Guo, Z.G., Ramanathan, S., Dominant interneuron activity in Caenorhabditis elegans to evoke chemotactic behavior, Nature (2012) 490 273-277.
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